2ged

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{{STRUCTURE_2ged| PDB=2ged | SCENE= }}
{{STRUCTURE_2ged| PDB=2ged | SCENE= }}
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'''Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form'''
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===Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form===
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==Overview==
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Protein translocation across and insertion into membranes is essential to all life forms. Signal peptide-bearing nascent polypeptide chains emerging from the ribosome are first sampled by the signal-recognition particle (SRP), then targeted to the membrane via the SRP receptor (SR), and, finally, transferred to the protein-conducting channel. In eukaryotes, this process is tightly controlled by the concerted action of three G proteins, the 54-kD subunit of SRP and the alpha- and beta-subunits of SR. We have determined the 2.2-A crystal structure of the nucleotide-free SRbeta domain. Unexpectedly, the structure is a homodimer with a highly intertwined interface made up of residues from the switch regions of the G domain. The remodeling of the switch regions does not resemble any of the known G protein switch mechanisms. Biochemical analysis confirms homodimerization in vitro, which is incompatible with SRalpha binding. The switch mechanism involves cis/trans isomerization of a strictly conserved proline, potentially implying a new layer of regulation of cotranslational transport.
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(as it appears on PubMed at http://www.pubmed.gov), where 16627619 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16627619}}
==About this Structure==
==About this Structure==
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[[Category: Protein transport]]
[[Category: Protein transport]]
[[Category: Signal recognition particle]]
[[Category: Signal recognition particle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:00:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:15 2008''

Revision as of 00:59, 29 July 2008

Image:2ged.png

Template:STRUCTURE 2ged

Signal Recognition Particle Receptor Beta-Subunit in nucleotide-free dimerized form

Template:ABSTRACT PUBMED 16627619

About this Structure

2GED is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Homodimerization of the G protein SRbeta in the nucleotide-free state involves proline cis/trans isomerization in the switch II region., Schwartz TU, Schmidt D, Brohawn SG, Blobel G, Proc Natl Acad Sci U S A. 2006 May 2;103(18):6823-8. Epub 2006 Apr 20. PMID:16627619

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