2b07

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2b07.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2b07.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b07| PDB=2b07 | SCENE= }}
{{STRUCTURE_2b07| PDB=2b07 | SCENE= }}
-
'''Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.'''
+
===Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.===
-
==Overview==
+
<!--
-
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16303309}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16303309}}
==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Tricyclic thiophene]]
[[Category: Tricyclic thiophene]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:41:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:47 2008''

Revision as of 00:59, 29 July 2008

Image:2b07.png

Template:STRUCTURE 2b07

Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.

Template:ABSTRACT PUBMED 16303309

About this Structure

2B07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors., Moretto AF, Kirincich SJ, Xu WX, Smith MJ, Wan ZK, Wilson DP, Follows BC, Binnun E, Joseph-McCarthy D, Foreman K, Erbe DV, Zhang YL, Tam SK, Tam SY, Lee J, Bioorg Med Chem. 2006 Apr 1;14(7):2162-77. Epub 2005 Nov 21. PMID:16303309

Page seeded by OCA on Tue Jul 29 03:59:47 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2b07"
Personal tools