1pv0

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{{STRUCTURE_1pv0| PDB=1pv0 | SCENE= }}
{{STRUCTURE_1pv0| PDB=1pv0 | SCENE= }}
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'''Structure of the Sda antikinase'''
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===Structure of the Sda antikinase===
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==Overview==
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Histidine kinases are used extensively in prokaryotes to monitor and respond to changes in cellular and environmental conditions. In Bacillus subtilis, sporulation-specific gene expression is controlled by a histidine kinase phosphorelay that culminates in phosphorylation of the Spo0A transcription factor. Sda provides a developmental checkpoint by inhibiting this phosphorelay in response to DNA damage and replication defects. We show that Sda acts at the first step in the relay by inhibiting autophosphorylation of the histidine kinase KinA. The structure of Sda, which we determined using NMR, comprises a helical hairpin. A cluster of conserved residues on one face of the hairpin mediates an interaction between Sda and the KinA dimerization/phosphotransfer domain. This interaction stabilizes the KinA dimer, and the two proteins form a stable heterotetramer. The data indicate that Sda forms a molecular barricade that inhibits productive interaction between the catalytic and phosphotransfer domains of KinA.
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(as it appears on PubMed at http://www.pubmed.gov), where 15023339 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15023339}}
==About this Structure==
==About this Structure==
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1PV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV0 OCA].
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1PV0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PV0 OCA].
==Reference==
==Reference==
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[[Category: Sda]]
[[Category: Sda]]
[[Category: Sporulation phosphorelay]]
[[Category: Sporulation phosphorelay]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:30:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:07:50 2008''

Revision as of 01:07, 29 July 2008

Image:1pv0.png

Template:STRUCTURE 1pv0

Structure of the Sda antikinase

Template:ABSTRACT PUBMED 15023339

About this Structure

1PV0 is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis., Rowland SL, Burkholder WF, Cunningham KA, Maciejewski MW, Grossman AD, King GF, Mol Cell. 2004 Mar 12;13(5):689-701. PMID:15023339

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