1z56

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[[Image:1z56.gif|left|200px]]
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{{Seed}}
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[[Image:1z56.png|left|200px]]
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{{STRUCTURE_1z56| PDB=1z56 | SCENE= }}
{{STRUCTURE_1z56| PDB=1z56 | SCENE= }}
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'''Co-Crystal Structure of Lif1p-Lig4p'''
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===Co-Crystal Structure of Lif1p-Lig4p===
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==Overview==
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DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the Xrcc4 'genome-guardian', an essential NHEJ factor. Here we report the 3.9 A crystal structure of the Saccharomyces cerevisiae Xrcc4 ortholog ligase interacting factor 1 (Lif1p) complexed with the C-terminal BRCT domains of DNA ligase IV (Lig4p). The structure reveals a novel mode of protein recognition by a tandem BRCT repeat, and in addition provides a molecular basis for a human LIG4 syndrome clinical condition.
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The line below this paragraph, {{ABSTRACT_PUBMED_16388993}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16388993 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16388993}}
==About this Structure==
==About this Structure==
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[[Category: Nhej]]
[[Category: Nhej]]
[[Category: Xrcc4]]
[[Category: Xrcc4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:11:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:08:57 2008''

Revision as of 01:09, 29 July 2008

Image:1z56.png

Template:STRUCTURE 1z56

Co-Crystal Structure of Lif1p-Lig4p

Template:ABSTRACT PUBMED 16388993

About this Structure

1Z56 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:16388993

Page seeded by OCA on Tue Jul 29 04:08:57 2008

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