1rjt

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{{Seed}}
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[[Image:1rjt.png|left|200px]]
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{{STRUCTURE_1rjt| PDB=1rjt | SCENE= }}
{{STRUCTURE_1rjt| PDB=1rjt | SCENE= }}
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'''NMR Structure of CXC Chemokine CXCL11/ITAC'''
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===NMR Structure of CXC Chemokine CXCL11/ITAC===
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==Overview==
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CXCL11 (ITAC) is one of three chemokines known to bind the receptor CXCR3, the two others being CXCL9 (Mig) and CXCL10 (IP-10). CXCL11 differs from the other CXCR3 ligands in both the strength and the particularities of its receptor interactions: It has a higher affinity, is a stronger agonist, and behaves differently when critical N-terminal residues are deleted. The structure of CXCL11 was determined using solution NMR to allow comparison with that of CXCL10 and help elucidate the source of the differences. CXCL11 takes on the canonical chemokine fold but exhibits greater conformational flexibility than has been observed for related chemokines under the same sample conditions. Unlike related chemokines such as IP-10 and IL-8, ITAC does not appear to form dimers at millimolar concentrations. The origin for this behavior can be found in the solution structure, which indicates a beta-bulge in beta-strand 1 that distorts the dimerization interface used by other CXC chemokines.
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The line below this paragraph, {{ABSTRACT_PUBMED_15273303}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15273303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15273303}}
==About this Structure==
==About this Structure==
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1RJT is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJT OCA].
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1RJT is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJT OCA].
==Reference==
==Reference==
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[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
[[Category: Chemokine]]
[[Category: Chemokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:35:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:15:05 2008''

Revision as of 01:15, 29 July 2008

Image:1rjt.png

Template:STRUCTURE 1rjt

NMR Structure of CXC Chemokine CXCL11/ITAC

Template:ABSTRACT PUBMED 15273303

About this Structure

1RJT is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structure of CXCR3 binding chemokine CXCL11 (ITAC)., Booth V, Clark-Lewis I, Sykes BD, Protein Sci. 2004 Aug;13(8):2022-8. PMID:15273303

Page seeded by OCA on Tue Jul 29 04:15:05 2008

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