1jxo

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{{STRUCTURE_1jxo| PDB=1jxo | SCENE= }}
{{STRUCTURE_1jxo| PDB=1jxo | SCENE= }}
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'''Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95'''
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===Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95===
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==Overview==
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PSD-95/SAP90 is a member of the MAGUK superfamily. In excitatory synapses, PSD-95 clusters receptors and ion channels at specific sites in the postsynaptic membrane and organizes downstream signaling and cytoskeletal molecules. We have determined the crystal structures of the apo and GMP-bound forms to 2.3 and 2.0 A resolutions, respectively, of a fragment containing the SH3, HOOK, and guanylate kinase (GK) domains of PSD-95. We observe an intramolecular interaction between the SH3 and GK domains involving the formation of a beta sheet including residues N- and C-terminal to the GK domain. Based on amino acid conservation and mutational data available in the literature, we propose that this intramolecular interaction is a common feature among MAGUK proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 11779506 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11779506}}
==About this Structure==
==About this Structure==
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[[Category: Postsynaptic density]]
[[Category: Postsynaptic density]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:03:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:15:06 2008''

Revision as of 01:15, 29 July 2008

Image:1jxo.png

Template:STRUCTURE 1jxo

Crystal Structure of the SH3-HOOK-GK Fragment of PSD-95

Template:ABSTRACT PUBMED 11779506

About this Structure

1JXO is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural characterization of the intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95., Tavares GA, Panepucci EH, Brunger AT, Mol Cell. 2001 Dec;8(6):1313-25. PMID:11779506

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