2oi7

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{{STRUCTURE_2oi7| PDB=2oi7 | SCENE= }}
{{STRUCTURE_2oi7| PDB=2oi7 | SCENE= }}
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'''E. coli GlmU- Complex with UDP-GlcNAc, desulpho-CoA and GlcNAc-1-PO4'''
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===E. coli GlmU- Complex with UDP-GlcNAc, desulpho-CoA and GlcNAc-1-PO4===
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==Overview==
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The biosynthesis of UDP-GlcNAc in bacteria is carried out by GlmU, an essential bifunctional uridyltransferase that catalyzes the CoA-dependent acetylation of GlcN-1-PO(4) to form GlcNAc-1-PO(4) and its subsequent condensation with UTP to form pyrophosphate and UDP-GlcNAc. As a metabolite, UDP-GlcNAc is situated at a branch point leading to the biosynthesis of lipopolysaccharide and peptidoglycan. Consequently, GlmU is regarded as an important target for potential antibacterial agents. The crystal structure of the Escherichia coli GlmU acetyltransferase active site has been determined in complexes with acetyl-CoA, CoA/GlcN-1-PO(4), and desulpho-CoA/GlcNAc-1-PO(4). These structures reveal the enzyme groups responsible for binding the substrates. A superposition of these complex structures suggests that the 2-amino group of GlcN-1-PO(4) is positioned in proximity to the acetyl-CoA to facilitate direct attack on its thioester by a ternary complex mechanism.
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{{ABSTRACT_PUBMED_17473010}}
==About this Structure==
==About this Structure==
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[[Category: Vetting, M W.]]
[[Category: Vetting, M W.]]
[[Category: Left-handed beta helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:58:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:15:55 2008''

Revision as of 01:16, 29 July 2008

Image:2oi7.png

Template:STRUCTURE 2oi7

E. coli GlmU- Complex with UDP-GlcNAc, desulpho-CoA and GlcNAc-1-PO4

Template:ABSTRACT PUBMED 17473010

About this Structure

2OI7 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the E. coli bifunctional GlmU acetyltransferase active site with substrates and products., Olsen LR, Vetting MW, Roderick SL, Protein Sci. 2007 Jun;16(6):1230-5. Epub 2007 May 1. PMID:17473010

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