This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1si1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1si1.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1si1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1si1| PDB=1si1 | SCENE= }}
{{STRUCTURE_1si1| PDB=1si1 | SCENE= }}
-
'''Crystal Structure of Mannheimia haemolytica Ferric iron-Binding Protein A in an open conformation'''
+
===Crystal Structure of Mannheimia haemolytica Ferric iron-Binding Protein A in an open conformation===
-
==Overview==
+
<!--
-
We have determined the 1.35- and 1.45-A structures, respectively, of closed and open iron-loaded forms of Mannheimia haemolytica ferric ion-binding protein A. M. haemolytica is the causative agent in the economically important and fatal disease of cattle termed shipping fever. The periplasmic iron-binding protein of this gram-negative bacterium, which has homologous counterparts in many other pathogenic species, performs a key role in iron acquisition from mammalian host serum iron transport proteins and is essential for the survival of the pathogen within the host. The ferric (Fe(3+)) ion in the closed structure is bound by a novel asymmetric constellation of four ligands, including a synergistic carbonate anion. The open structure is ligated by three tyrosyl residues and a dynamically disordered solvent-exposed anion. Our results clearly implicate the synergistic anion as the primary mediator of global protein conformation and provide detailed insights into the molecular mechanisms of iron binding and release in the periplasm.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15175304}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15175304 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15175304}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Tari, L W.]]
[[Category: Tari, L W.]]
[[Category: Metal binding protein]]
[[Category: Metal binding protein]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:43:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:18:08 2008''

Revision as of 01:18, 29 July 2008

Image:1si1.png

Template:STRUCTURE 1si1

Crystal Structure of Mannheimia haemolytica Ferric iron-Binding Protein A in an open conformation

Template:ABSTRACT PUBMED 15175304

About this Structure

1SI1 is a Single protein structure of sequence from Mannheimia haemolytica. Full crystallographic information is available from OCA.

Reference

Structural basis for iron binding and release by a novel class of periplasmic iron-binding proteins found in gram-negative pathogens., Shouldice SR, Skene RJ, Dougan DR, Snell G, McRee DE, Schryvers AB, Tari LW, J Bacteriol. 2004 Jun;186(12):3903-10. PMID:15175304

Page seeded by OCA on Tue Jul 29 04:18:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1si1"
Personal tools