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1rb4

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{{STRUCTURE_1rb4| PDB=1rb4 | SCENE= }}
{{STRUCTURE_1rb4| PDB=1rb4 | SCENE= }}
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'''ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TETRAGONAL AUTOMATIC SOLUTION'''
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===ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TETRAGONAL AUTOMATIC SOLUTION===
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==Overview==
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Efficient determination of protein crystal structures requires automated x-ray data analysis. Here, we describe the expert system ELVES and its use to determine automatically the structure of a 12-kDa protein. Multiwavelength anomalous diffraction analysis of a selenomethionyl derivative was used to image the Asn-16-Ala variant of the GCN4 leucine zipper. In contrast to the parallel, dimeric coiled coil formed by the WT sequence, the mutant unexpectedly formed an antiparallel trimer. This structural switch reveals how avoidance of core cavities at a single site can select the native fold of a protein. All structure calculations, including indexing, data processing, locating heavy atoms, phasing by multiwavelength anomalous diffraction, model building, and refinement, were completed without human intervention. The results demonstrate the feasibility of automated methods for determining high-resolution, x-ray crystal structures of proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_14752198}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14752198 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14752198}}
==About this Structure==
==About this Structure==
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[[Category: Leucine zipper]]
[[Category: Leucine zipper]]
[[Category: Peptide]]
[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:17:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:18:49 2008''

Revision as of 01:18, 29 July 2008

Image:1rb4.png

Template:STRUCTURE 1rb4

ANTIPARALLEL TRIMER OF GCN4-LEUCINE ZIPPER CORE MUTANT AS N16A TETRAGONAL AUTOMATIC SOLUTION

Template:ABSTRACT PUBMED 14752198

About this Structure

1RB4 is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Automated protein crystal structure determination using ELVES., Holton J, Alber T, Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1537-42. Epub 2004 Jan 29. PMID:14752198

Page seeded by OCA on Tue Jul 29 04:18:49 2008

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