1ssl

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{{STRUCTURE_1ssl| PDB=1ssl | SCENE= }}
{{STRUCTURE_1ssl| PDB=1ssl | SCENE= }}
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'''Solution structure of the PSI domain from the Met receptor'''
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===Solution structure of the PSI domain from the Met receptor===
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==Overview==
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PSI domains are cysteine-rich modules found in extracellular fragments of hundreds of signaling proteins, including plexins, semaphorins, integrins, and attractins. Here, we report the solution structure of the PSI domain from the human Met receptor, a receptor tyrosine kinase critical for proliferation, motility, and differentiation. The structure represents a cysteine knot with short regions of secondary structure including a three-stranded antiparallel beta-sheet and two alpha-helices. All eight cysteines are involved in disulfide bonds with the pattern consistent with that for the PSI domain from Sema4D. Comparison with the Sema4D structure identifies a structurally conserved core comprising the N-terminal half of the PSI domain. Interestingly, this part links adjacent SEMA and immunoglobulin domains in the Sema4D structure, suggesting that the PSI domain serves as a wedge between propeller and immunoglobulin domains and is responsible for the correct positioning of the ligand-binding site of the receptor.
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{{ABSTRACT_PUBMED_15358240}}
==About this Structure==
==About this Structure==
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1SSL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSL OCA].
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1SSL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSL OCA].
==Reference==
==Reference==
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[[Category: Schrag, J D.]]
[[Category: Schrag, J D.]]
[[Category: Cysteine knot]]
[[Category: Cysteine knot]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:05:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:18:50 2008''

Revision as of 01:19, 29 July 2008

Image:1ssl.png

Template:STRUCTURE 1ssl

Solution structure of the PSI domain from the Met receptor

Template:ABSTRACT PUBMED 15358240

About this Structure

1SSL is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Insights into function of PSI domains from structure of the Met receptor PSI domain., Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I, Biochem Biophys Res Commun. 2004 Aug 13;321(1):234-40. PMID:15358240

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