1w1p

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[[Image:1w1p.gif|left|200px]]
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{{STRUCTURE_1w1p| PDB=1w1p | SCENE= }}
{{STRUCTURE_1w1p| PDB=1w1p | SCENE= }}
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'''CRYSTAL STRUCTURE OF S. MARCESCENS CHITINASE B IN COMPLEX WITH THE CYCLIC DIPEPTIDE INHIBITOR CYCLO-(GLY-L-PRO) AT 2.1 A RESOLUTION'''
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===CRYSTAL STRUCTURE OF S. MARCESCENS CHITINASE B IN COMPLEX WITH THE CYCLIC DIPEPTIDE INHIBITOR CYCLO-(GLY-L-PRO) AT 2.1 A RESOLUTION===
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==Overview==
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Family 18 chitinases play an essential role in a range of pathogens and pests. Several inhibitors are known, including the potent inhibitors argadin and allosamidin, and the structures of these in complex with chitinases have been elucidated. Recent structural analysis has revealed that CI-4 [cyclo-(L-Arg-D-Pro)] inhibits family 18 chitinases by mimicking the structure of the proposed reaction intermediate. Here we report the high-resolution structures of four new CI-4 derivatives, cyclo-(L-Arg-L-Pro), cyclo-(Gly-L-Pro), cyclo-(L-His-L-Pro), and cyclo-(L-Tyr-L-Pro), in complex with a family 18 chitinase. In addition, details of enzyme inhibition and in vivo activity against Saccharomyces cerevisiae are presented. The structures reveal that the common cyclo-(Gly-Pro) substructure is sufficient for binding, allowing modification of the side chain of the nonproline residue. This suggests that design of cyclic dipeptides with a view to increasing inhibition of family 18 chitinases should be possible through relatively accessible chemistry. The derivatives presented here in complex with chitinase B from Serratia marcescens provide further insight into the mechanism of inhibition of chitinases by cyclic dipeptides as well as providing a new scaffold for chitinase inhibitor design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15509170 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15509170}}
==About this Structure==
==About this Structure==
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[[Category: Glycoside hydrolase]]
[[Category: Glycoside hydrolase]]
[[Category: Structure-based inhibitor design]]
[[Category: Structure-based inhibitor design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:22:05 2008''

Revision as of 01:22, 29 July 2008

Image:1w1p.png

Template:STRUCTURE 1w1p

CRYSTAL STRUCTURE OF S. MARCESCENS CHITINASE B IN COMPLEX WITH THE CYCLIC DIPEPTIDE INHIBITOR CYCLO-(GLY-L-PRO) AT 2.1 A RESOLUTION

Template:ABSTRACT PUBMED 15509170

About this Structure

1W1P is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

Structure-based exploration of cyclic dipeptide chitinase inhibitors., Houston DR, Synstad B, Eijsink VG, Stark MJ, Eggleston IM, van Aalten DM, J Med Chem. 2004 Nov 4;47(23):5713-20. PMID:15509170

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