1wms

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{{STRUCTURE_1wms| PDB=1wms | SCENE= }}
{{STRUCTURE_1wms| PDB=1wms | SCENE= }}
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'''High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target'''
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===High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target===
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==Overview==
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Rab GTPases and their effectors facilitate vesicular transport by tethering donor vesicles to their respective target membranes. Rab9 mediates late endosome to trans-Golgi transport and has recently been found to be a key cellular component for human immunodeficiency virus-1, Ebola, Marburg, and measles virus replication, suggesting that it may be a novel target in the development of broad spectrum antiviral drugs. As part of our structure-based drug design program, we have determined the crystal structure of a C-terminally truncated human Rab9 (residues 1-177) to 1.25-A resolution. The overall structure shows a characteristic nucleotide binding fold consisting of a six-stranded beta-sheet surrounded by five alpha-helices with a tightly bound GDP molecule in the active site. Structure-based sequence alignment of Rab9 with other Rab proteins reveals that its active site consists of residues highly conserved in the Rab GTPase family, implying a common catalytic mechanism. However, Rab9 contains seven regions that are significantly different in conformation from other Rab proteins. Some of those regions coincide with putative effector-binding sites and switch I and switch II regions identified by structure/sequence alignments. The Rab9 structure at near atomic resolution provides an excellent model for structure-based antiviral drug design.
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(as it appears on PubMed at http://www.pubmed.gov), where 15263003 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15263003}}
==About this Structure==
==About this Structure==
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[[Category: Zhou, X E.]]
[[Category: Zhou, X E.]]
[[Category: Gtpase]]
[[Category: Gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:53:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:23:57 2008''

Revision as of 01:24, 29 July 2008

Image:1wms.png

Template:STRUCTURE 1wms

High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target

Template:ABSTRACT PUBMED 15263003

About this Structure

1WMS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target., Chen L, DiGiammarino E, Zhou XE, Wang Y, Toh D, Hodge TW, Meehan EJ, J Biol Chem. 2004 Sep 17;279(38):40204-8. Epub 2004 Jul 19. PMID:15263003

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