2h9x

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{{STRUCTURE_2h9x| PDB=2h9x | SCENE= }}
{{STRUCTURE_2h9x| PDB=2h9x | SCENE= }}
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'''NMR structure for the CgNa toxin from the sea anemone Condylactis gigantea'''
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===NMR structure for the CgNa toxin from the sea anemone Condylactis gigantea===
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==Overview==
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CgNa (Condylactis gigantea neurotoxin) is a 47-amino-acid- residue toxin from the giant Caribbean sea anemone Condylactis gigantea. The structure of CgNa, which was solved by 1H-NMR spectroscopy, is somewhat atypical and displays significant homology with both type I and II anemone toxins. CgNa also displays a considerable number of exceptions to the canonical structural elements that are thought to be essential for the activity of this group of toxins. Furthermore, unique residues in CgNa define a characteristic structure with strong negatively charged surface patches. These patches disrupt a surface-exposed cluster of hydrophobic residues present in all anemone-derived toxins described to date. A thorough characterization by patch-clamp analysis using rat DRG (dorsal root ganglion) neurons indicated that CgNa preferentially binds to TTX-S (tetrodotoxin-sensitive) voltage-gated sodium channels in the resting state. This association increased the inactivation time constant and the rate of recovery from inactivation, inducing a significant shift in the steady state of inactivation curve to the left. The specific structural features of CgNa may explain its weaker inhibitory capacity when compared with the other type I and II anemone toxins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17506725 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17506725}}
==About this Structure==
==About this Structure==
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2H9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Condylactis_gigantea Condylactis gigantea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9X OCA].
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2H9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Condylactis_gigantea Condylactis gigantea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H9X OCA].
==Reference==
==Reference==
CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1)., Salceda E, Perez-Castells J, Lopez-Mendez B, Garateix A, Salazar H, Lopez O, Aneiros A, Standker L, Beress L, Forssmann WG, Soto E, Jimenez-Barbero J, Gimenez-Gallego G, Biochem J. 2007 Aug 15;406(1):67-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17506725 17506725]
CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1)., Salceda E, Perez-Castells J, Lopez-Mendez B, Garateix A, Salazar H, Lopez O, Aneiros A, Standker L, Beress L, Forssmann WG, Soto E, Jimenez-Barbero J, Gimenez-Gallego G, Biochem J. 2007 Aug 15;406(1):67-76. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17506725 17506725]
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A new toxin from the sea anemone Condylactis gigantea with effect on sodium channel inactivation., Standker L, Beress L, Garateix A, Christ T, Ravens U, Salceda E, Soto E, John H, Forssmann WG, Aneiros A, Toxicon. 2006 Aug;48(2):211-20. Epub 2006 May 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16814340 16814340]
[[Category: Condylactis gigantea]]
[[Category: Condylactis gigantea]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Perez-Castells, J.]]
[[Category: Perez-Castells, J.]]
[[Category: Beta sheet]]
[[Category: Beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:24:38 2008''

Revision as of 01:24, 29 July 2008

Image:2h9x.png

Template:STRUCTURE 2h9x

NMR structure for the CgNa toxin from the sea anemone Condylactis gigantea

Template:ABSTRACT PUBMED 17506725

About this Structure

2H9X is a Single protein structure of sequence from Condylactis gigantea. Full experimental information is available from OCA.

Reference

CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1)., Salceda E, Perez-Castells J, Lopez-Mendez B, Garateix A, Salazar H, Lopez O, Aneiros A, Standker L, Beress L, Forssmann WG, Soto E, Jimenez-Barbero J, Gimenez-Gallego G, Biochem J. 2007 Aug 15;406(1):67-76. PMID:17506725

A new toxin from the sea anemone Condylactis gigantea with effect on sodium channel inactivation., Standker L, Beress L, Garateix A, Christ T, Ravens U, Salceda E, Soto E, John H, Forssmann WG, Aneiros A, Toxicon. 2006 Aug;48(2):211-20. Epub 2006 May 19. PMID:16814340

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