1sb1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1sb1.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1sb1.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1sb1| PDB=1sb1 | SCENE= }}
{{STRUCTURE_1sb1| PDB=1sb1 | SCENE= }}
-
'''Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics'''
+
===Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics===
-
==Overview==
+
<!--
-
The design, synthesis and biological activity of a series of novel non-covalent D-Phe-Pro-Arg motif-based thrombin inhibitors incorporating 4,5,6,7-tetrahydrobenzothiazol-2-amine as a novel arginine surrogate are described. Compound 9, the most potent in the series of thrombin inhibitors, exhibited an in vitro K(i) of 128 nM and 342-fold selectivity against trypsin. The binding mode of this novel class of thrombin inhibitors in the enzyme active site, based on the X-ray crystal structure of compound 9 co-crystallized with human alpha-thrombin, is discussed.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15051174}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15051174 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15051174}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Thrombin]]
[[Category: Thrombin]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:29:54 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:25:37 2008''

Revision as of 01:25, 29 July 2008

Image:1sb1.png

Template:STRUCTURE 1sb1

Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics

Template:ABSTRACT PUBMED 15051174

About this Structure

1SB1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics., Marinko P, Krbavcic A, Mlinsek G, Solmajer T, Bakija AT, Stegnar M, Stojan J, Kikelj D, Eur J Med Chem. 2004 Mar;39(3):257-65. PMID:15051174

Page seeded by OCA on Tue Jul 29 04:25:37 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sb1"
Personal tools