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1y42

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[[Image:1y42.gif|left|200px]]
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{{STRUCTURE_1y42| PDB=1y42 | SCENE= }}
{{STRUCTURE_1y42| PDB=1y42 | SCENE= }}
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'''Crystal structure of a C-terminally truncated CYT-18 protein'''
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===Crystal structure of a C-terminally truncated CYT-18 protein===
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==Overview==
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We determined a 1.95 A X-ray crystal structure of a C-terminally truncated Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (CYT-18 protein) that functions in splicing group I introns. CYT-18's nucleotide binding fold and intermediate alpha-helical domains superimpose on those of bacterial TyrRSs, except for an N-terminal extension and two small insertions not found in nonsplicing bacterial enzymes. These additions surround the cyt-18-1 mutation site and are sites of suppressor mutations that restore splicing, but not synthetase activity. Highly constrained models based on directed hydroxyl radical cleavage assays show that the group I intron binds at a site formed in part by the three additions on the nucleotide binding fold surface opposite that which binds tRNATyr. Our results show how essential proteins can progressively evolve new functions.
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(as it appears on PubMed at http://www.pubmed.gov), where 15694342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15694342}}
==About this Structure==
==About this Structure==
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[[Category: Trna ligase]]
[[Category: Trna ligase]]
[[Category: Tyrosyl trna synthetase]]
[[Category: Tyrosyl trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:51:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:25:35 2008''

Revision as of 01:25, 29 July 2008

Image:1y42.png

Template:STRUCTURE 1y42

Crystal structure of a C-terminally truncated CYT-18 protein

Template:ABSTRACT PUBMED 15694342

About this Structure

1Y42 is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

A tyrosyl-tRNA synthetase adapted to function in group I intron splicing by acquiring a new RNA binding surface., Paukstelis PJ, Coon R, Madabusi L, Nowakowski J, Monzingo A, Robertus J, Lambowitz AM, Mol Cell. 2005 Feb 4;17(3):417-28. PMID:15694342

Page seeded by OCA on Tue Jul 29 04:25:35 2008

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