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1qe0

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[[Image:1qe0.gif|left|200px]]
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{{Seed}}
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[[Image:1qe0.png|left|200px]]
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{{STRUCTURE_1qe0| PDB=1qe0 | SCENE= }}
{{STRUCTURE_1qe0| PDB=1qe0 | SCENE= }}
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'''CRYSTAL STRUCTURE OF APO S. AUREUS HISTIDYL-TRNA SYNTHETASE'''
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===CRYSTAL STRUCTURE OF APO S. AUREUS HISTIDYL-TRNA SYNTHETASE===
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==Overview==
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The crystal structure of the Staphylococcus aureus histidyl-tRNA synthetase apoprotein has been determined at 2.7 A resolution. Several important loops in the active site either become disordered or adopt very different conformations compared to their ligand-bound states. These include the histidine A motif (Arg257-Tyr262) that is essential for substrate recognition, a loop (Gly52-Lys62) that seems to control the communication between the histidine and ATP binding sites, the motif 2 loop (Glu114-Arg120) that binds ATP, and the insertion domain that is likely to bind tRNA. These ligand-induced structural changes are supported by fluorescence experiments, which also suggest highly cooperative dynamics. A dynamic and cooperative active site is most likely necessary for the proper functioning of the histidyl-tRNA synthetase, and suggests a novel mechanism for improving charging fidelity.
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The line below this paragraph, {{ABSTRACT_PUBMED_10493797}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10493797 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10493797}}
==About this Structure==
==About this Structure==
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[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: Class ii trna synthetase]]
[[Category: Class ii trna synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:10:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:27:20 2008''

Revision as of 01:27, 29 July 2008

Image:1qe0.png

Template:STRUCTURE 1qe0

CRYSTAL STRUCTURE OF APO S. AUREUS HISTIDYL-TRNA SYNTHETASE

Template:ABSTRACT PUBMED 10493797

About this Structure

1QE0 is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases., Qiu X, Janson CA, Blackburn MN, Chhohan IK, Hibbs M, Abdel-Meguid SS, Biochemistry. 1999 Sep 21;38(38):12296-304. PMID:10493797

Page seeded by OCA on Tue Jul 29 04:27:20 2008

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