2bz8

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{{STRUCTURE_2bz8| PDB=2bz8 | SCENE= }}
{{STRUCTURE_2bz8| PDB=2bz8 | SCENE= }}
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'''N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE'''
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===N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE===
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==Overview==
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The ubiquitin ligases c-Cbl and Cbl-b play a crucial role in receptor downregulation by mediating multiple monoubiquitination of receptors and promoting their sorting for lysosomal degradation. Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis. We report the structures of SH3 domains of CIN85 and beta-PIX in complex with a proline-arginine peptide from Cbl-b. Both structures reveal a heterotrimeric complex containing two SH3 domains held together by a single peptide. Trimerization also occurs in solution and is facilitated by the pseudo-symmetrical peptide sequence. Moreover, ternary complexes of CIN85 and Cbl are formed in vivo and are important for the ability of Cbl to promote epidermal growth factor receptor (EGFR) downregulation. These results provide molecular explanations for a novel mechanism by which Cbl controls receptor downregulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16228008 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16228008}}
==About this Structure==
==About this Structure==
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[[Category: Endocytosis]]
[[Category: Endocytosis]]
[[Category: Sh3 domain]]
[[Category: Sh3 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 21:00:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:27:34 2008''

Revision as of 01:27, 29 July 2008

Image:2bz8.png

Template:STRUCTURE 2bz8

N-TERMINAL SH3 DOMAIN OF CIN85 BOUND TO CBL-B PEPTIDE

Template:ABSTRACT PUBMED 16228008

About this Structure

2BZ8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cbl promotes clustering of endocytic adaptor proteins., Jozic D, Cardenes N, Deribe YL, Moncalian G, Hoeller D, Groemping Y, Dikic I, Rittinger K, Bravo J, Nat Struct Mol Biol. 2005 Nov;12(11):972-9. PMID:16228008

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