1oaz

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[[Image:1oaz.jpg|left|200px]]
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{{Seed}}
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[[Image:1oaz.png|left|200px]]
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{{STRUCTURE_1oaz| PDB=1oaz | SCENE= }}
{{STRUCTURE_1oaz| PDB=1oaz | SCENE= }}
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'''IGE FV SPE7 COMPLEXED WITH A RECOMBINANT THIOREDOXIN'''
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===IGE FV SPE7 COMPLEXED WITH A RECOMBINANT THIOREDOXIN===
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==Overview==
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A single antibody was shown to adopt different binding-site conformations and thereby bind unrelated antigens. Analysis by both x-ray crystallography and pre-steady-state kinetics revealed an equilibrium between different preexisting isomers, one of which possessed a promiscuous, low-affinity binding site for aromatic ligands, including the immunizing hapten. A subsequent induced-fit isomerization led to high-affinity complexes with a deep and narrow binding site. A protein antigen identified by repertoire selection made use of an unrelated antibody isomer with a wide, shallow binding site. Conformational diversity, whereby one sequence adopts multiple structures and multiple functions, can increase the effective size of the antibody repertoire but may also lead to autoimmunity and allergy.
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The line below this paragraph, {{ABSTRACT_PUBMED_12610298}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12610298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12610298}}
==About this Structure==
==About this Structure==
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[[Category: Ige]]
[[Category: Ige]]
[[Category: Multispecficity,redox-active center,electron transport]]
[[Category: Multispecficity,redox-active center,electron transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:36:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:33:57 2008''

Revision as of 01:34, 29 July 2008

Image:1oaz.png

Template:STRUCTURE 1oaz

IGE FV SPE7 COMPLEXED WITH A RECOMBINANT THIOREDOXIN

Template:ABSTRACT PUBMED 12610298

About this Structure

1OAZ is a Single protein structure of sequence from Escherichia coli and Rattus rattus. Full crystallographic information is available from OCA.

Reference

Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298

Page seeded by OCA on Tue Jul 29 04:33:57 2008

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