1qs4

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{{STRUCTURE_1qs4| PDB=1qs4 | SCENE= }}
{{STRUCTURE_1qs4| PDB=1qs4 | SCENE= }}
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'''Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone'''
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===Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone===
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==Overview==
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HIV integrase, the enzyme that inserts the viral DNA into the host chromosome, has no mammalian counterpart, making it an attractive target for antiviral drug design. As one of the three enzymes produced by HIV, it can be expected that inhibitors of this enzyme will complement the therapeutic use of HIV protease and reverse transcriptase inhibitors. We have determined the structure of a complex of the HIV-1 integrase core domain with a novel inhibitor, 5ClTEP, 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-pro penone, to 2.1-A resolution. The inhibitor binds centrally in the active site of the integrase and makes a number of close contacts with the protein. Only minor changes in the protein accompany inhibitor binding. This inhibitor complex will provide a platform for structure-based design of an additional class of inhibitors for antiviral therapy.
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{{ABSTRACT_PUBMED_10557269}}
==About this Structure==
==About this Structure==
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[[Category: Integrase]]
[[Category: Integrase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:38:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:34:40 2008''

Revision as of 01:34, 29 July 2008

Image:1qs4.png

Template:STRUCTURE 1qs4

Core domain of HIV-1 integrase complexed with Mg++ and 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone

Template:ABSTRACT PUBMED 10557269

About this Structure

1QS4 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design., Goldgur Y, Craigie R, Cohen GH, Fujiwara T, Yoshinaga T, Fujishita T, Sugimoto H, Endo T, Murai H, Davies DR, Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13040-3. PMID:10557269

Page seeded by OCA on Tue Jul 29 04:34:40 2008

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