2bc4

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[[Image:2bc4.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2bc4| PDB=2bc4 | SCENE= }}
{{STRUCTURE_2bc4| PDB=2bc4 | SCENE= }}
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'''Crystal structure of HLA-DM'''
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===Crystal structure of HLA-DM===
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==Overview==
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HLA-DM (DM) plays a critical role in Ag presentation to CD4 T cells by catalyzing the exchange of peptides bound to MHC class II molecules. Large lateral surfaces involved in the DM:HLA-DR (DR) interaction have been defined, but the mechanism of catalysis is not understood. In this study, we describe four small molecules that accelerate DM-catalyzed peptide exchange. Mechanistic studies demonstrate that these small molecules substantially enhance the catalytic efficiency of DM, indicating that they make the transition state of the DM:DR/peptide complex energetically more favorable. These compounds fall into two functional classes: two compounds are active only in the presence of DM, and binding data for one show a direct interaction with DM. The remaining two compounds have partial activity in the absence of DM, suggesting that they may act at the interface between DM and DR/peptide. A hydrophobic ridge in the DMbeta1 domain was implicated in the catalysis of peptide exchange because the activity of three of these enhancers was substantially reduced by point mutations in this area.
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The line below this paragraph, {{ABSTRACT_PUBMED_16547258}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16547258 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16547258}}
==About this Structure==
==About this Structure==
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[[Category: Xing, X.]]
[[Category: Xing, X.]]
[[Category: Mhc class ii]]
[[Category: Mhc class ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:36:56 2008''

Revision as of 01:36, 29 July 2008

Image:2bc4.png

Template:STRUCTURE 2bc4

Crystal structure of HLA-DM

Template:ABSTRACT PUBMED 16547258

About this Structure

2BC4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Small molecules that enhance the catalytic efficiency of HLA-DM., Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW, J Immunol. 2006 Apr 1;176(7):4208-20. PMID:16547258

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