1uon

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[[Image:1uon.gif|left|200px]]
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{{STRUCTURE_1uon| PDB=1uon | SCENE= }}
{{STRUCTURE_1uon| PDB=1uon | SCENE= }}
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'''REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION'''
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===REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION===
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==Overview==
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Reovirus is an icosahedral, double-stranded (ds) RNA virus that uses viral polymerases packaged within the viral core to transcribe its ten distinct plus-strand RNAs. To localize these polymerases, the structure of the reovirion was refined to a resolution of 7.6 A by cryo-electron microscopy (cryo-EM) and three-dimensional (3D) image reconstruction. X-ray crystal models of reovirus proteins, including polymerase lambda 3, were then fitted into the density map. Each copy of lambda 3 was found anchored to the inner surface of the icosahedral core shell, making major contacts with three molecules of shell protein lambda 1 and overlapping, but not centering on, a five-fold axis. The overlap explains why only one copy of lambda 3 is bound per vertex. lambda 3 is furthermore oriented with its transcript exit channel facing a small channel through the lambda 1 shell, suggesting how the nascent RNA is passed into the large external cavity of the pentameric capping enzyme complex formed by protein lambda 2.
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(as it appears on PubMed at http://www.pubmed.gov), where 14608373 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14608373}}
==About this Structure==
==About this Structure==
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[[Category: Polymerase]]
[[Category: Polymerase]]
[[Category: Reovirus]]
[[Category: Reovirus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 11:30:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:37:23 2008''

Revision as of 01:37, 29 July 2008

Image:1uon.png

Template:STRUCTURE 1uon

REOVIRUS POLYMERASE LAMBDA-3 LOCALIZED BY ELECTRON CRYOMICROSCOPY OF VIRIONS AT 7.6-A RESOLUTION

Template:ABSTRACT PUBMED 14608373

About this Structure

1UON is a Protein complex structure of sequences from Reovirus sp.. Full crystallographic information is available from OCA.

Reference

Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A., Zhang X, Walker SB, Chipman PR, Nibert ML, Baker TS, Nat Struct Biol. 2003 Dec;10(12):1011-8. Epub 2003 Nov 9. PMID:14608373

Page seeded by OCA on Tue Jul 29 04:37:23 2008

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