2bfy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bfy.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2bfy.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bfy| PDB=2bfy | SCENE= }}
{{STRUCTURE_2bfy| PDB=2bfy | SCENE= }}
-
'''COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.'''
+
===COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.===
-
==Overview==
+
<!--
-
Aurora family serine/threonine kinases control mitotic progression, and their deregulation is implicated in tumorigenesis. Aurora A and Aurora B, the best-characterized members of mammalian Aurora kinases, are approximately 60% identical but bind to unrelated activating subunits. The structure of the complex of Aurora A with the TPX2 activator has been reported previously. Here, we report the crystal structure of Aurora B in complex with the IN-box segment of the inner centromere protein (INCENP) activator and with the small molecule inhibitor Hesperadin. The Aurora B:INCENP complex is remarkably different from the Aurora A:TPX2 complex. INCENP forms a crown around the small lobe of Aurora B and induces the active conformation of the T loop allosterically. The structure represents an intermediate state of activation of Aurora B in which the Aurora B C-terminal segment stabilizes an open conformation of the catalytic cleft, and a critical ion pair in the kinase active site is impaired. Phosphorylation of two serines in the carboxyl terminus of INCENP generates the fully active kinase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15866179}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15866179 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15866179}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Mitosis]]
[[Category: Mitosis]]
[[Category: Transferase complex]]
[[Category: Transferase complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:14:13 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:46:35 2008''

Revision as of 01:46, 29 July 2008

Image:2bfy.png

Template:STRUCTURE 2bfy

COMPLEX OF AURORA-B WITH INCENP AND HESPERIDIN.

Template:ABSTRACT PUBMED 15866179

About this Structure

2BFY is a Protein complex structure of sequences from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin., Sessa F, Mapelli M, Ciferri C, Tarricone C, Areces LB, Schneider TR, Stukenberg PT, Musacchio A, Mol Cell. 2005 Apr 29;18(3):379-91. PMID:15866179

Page seeded by OCA on Tue Jul 29 04:46:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bfy"
Personal tools