We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2ga9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ga9.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2ga9.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2ga9| PDB=2ga9 | SCENE= }}
{{STRUCTURE_2ga9| PDB=2ga9 | SCENE= }}
-
'''Crystal Structure of the Heterodimeric Vaccinia Virus Polyadenylate Polymerase with Bound ATP-gamma-S'''
+
===Crystal Structure of the Heterodimeric Vaccinia Virus Polyadenylate Polymerase with Bound ATP-gamma-S===
-
==Overview==
+
<!--
-
Polyadenylation of mRNAs in poxviruses, crucial for virion maturation, is carried out by a poly(A) polymerase heterodimer composed of a catalytic component, VP55, and a processivity factor, VP39. The ATP-gamma-S bound and unbound crystal structures of the vaccinia polymerase reveal an unusual architecture for VP55 that comprises of N-terminal, central or catalytic, and C-terminal domains with different topologies and that differs from many polymerases, including the eukaryotic poly(A) polymerases. Residues in the active site of VP55, located between the catalytic and C-terminal domains, make specific interactions with the adenine of the ATP analog, establishing the molecular basis of ATP recognition. VP55's concave surface docks the globular VP39. A model for RNA primer binding that involves all three VP55 domains and VP39 is proposed. The model supports biochemical evidence that VP39 functions as a processivity factor by partially enclosing the RNA primer at the heterodimer interface.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16678106}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16678106 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16678106}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Poxvirus]]
[[Category: Poxvirus]]
[[Category: Processivity]]
[[Category: Processivity]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:52:45 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:48:50 2008''

Revision as of 01:48, 29 July 2008

Image:2ga9.png

Template:STRUCTURE 2ga9

Crystal Structure of the Heterodimeric Vaccinia Virus Polyadenylate Polymerase with Bound ATP-gamma-S

Template:ABSTRACT PUBMED 16678106

About this Structure

2GA9 is a Protein complex structure of sequences from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity., Moure CM, Bowman BR, Gershon PD, Quiocho FA, Mol Cell. 2006 May 5;22(3):339-49. PMID:16678106

Page seeded by OCA on Tue Jul 29 04:48:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ga9"
Personal tools