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1qwt

From Proteopedia

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{{STRUCTURE_1qwt| PDB=1qwt | SCENE= }}
{{STRUCTURE_1qwt| PDB=1qwt | SCENE= }}
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'''Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain'''
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===Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain===
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==Overview==
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IRF-3, a member of the interferon regulatory factor (IRF) family of transcription factors, functions as a molecular switch for antiviral activity. IRF-3 uses an autoinhibitory mechanism to suppress its transactivation potential in uninfected cells, and virus infection induces phosphorylation and activation of IRF-3 to initiate the antiviral responses. The crystal structure of the IRF-3 transactivation domain reveals a unique autoinhibitory mechanism, whereby the IRF association domain and the flanking autoinhibitory elements condense to form a hydrophobic core. The structure suggests that phosphorylation reorganizes the autoinhibitory elements, leading to unmasking of a hydrophobic active site and realignment of the DNA binding domain for transcriptional activation. IRF-3 exhibits marked structural and surface electrostatic potential similarity to the MH2 domain of the Smad protein family and the FHA domain, suggesting a common molecular mechanism of action among this superfamily of signaling mediators.
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(as it appears on PubMed at http://www.pubmed.gov), where 14555996 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14555996}}
==About this Structure==
==About this Structure==
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[[Category: Qin, B Y.]]
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[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:47:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:48:55 2008''

Revision as of 01:48, 29 July 2008

Image:1qwt.png

Template:STRUCTURE 1qwt

Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain

Template:ABSTRACT PUBMED 14555996

About this Structure

1QWT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation., Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K, Nat Struct Biol. 2003 Nov;10(11):913-21. Epub 2003 Oct 12. PMID:14555996

Page seeded by OCA on Tue Jul 29 04:48:55 2008

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