1z43

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{{STRUCTURE_1z43| PDB=1z43 | SCENE= }}
{{STRUCTURE_1z43| PDB=1z43 | SCENE= }}
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'''Crystal structure of 7S.S SRP RNA of M. jannaschii'''
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===Crystal structure of 7S.S SRP RNA of M. jannaschii===
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==Overview==
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Proper assembly of large protein-RNA complexes requires sequential binding of the proteins to the RNA. The signal recognition particle (SRP) is a multiprotein-RNA complex responsible for the cotranslational targeting of proteins to biological membranes. Here we describe the crystal structure at 2.6-A resolution of the S-domain of SRP RNA from the archeon Methanococcus jannaschii. Comparison of this structure with the SRP19-bound form reveals the nature of the SRP19-induced conformational changes, which promote subsequent SRP54 attachment. These structural changes are initiated at the SRP19 binding site and transmitted through helix 6 to looped-out adenosines, which form tertiary RNA interaction with helix 8. Displacement of these adenosines enforces a conformational change of the asymmetric loop structure in helix 8. In free RNA, the three unpaired bases A195, C196, and C197 are directed toward the helical axis, whereas upon SRP19 binding the loop backbone inverts and the bases are splayed out in a conformation that resembles the SRP54-bound form. Nucleotides adjacent to the bulged nucleotides seem to be particularly important in the regulation of this loop transition. Binding of SRP19 to 7S RNA reveals an elegant mechanism of how protein-induced changes are directed through an RNA molecule and may relate to those regulating the assembly of other RNPs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15928341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15928341}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural insights into SRP RNA: an induced fit mechanism for SRP assembly., Hainzl T, Huang S, Sauer-Eriksson AE, RNA. 2005 Jul;11(7):1043-50. Epub 2005 May 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15928341 15928341]
Structural insights into SRP RNA: an induced fit mechanism for SRP assembly., Hainzl T, Huang S, Sauer-Eriksson AE, RNA. 2005 Jul;11(7):1043-50. Epub 2005 May 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15928341 15928341]
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Structure of the SRP19 RNA complex and implications for signal recognition particle assembly., Hainzl T, Huang S, Sauer-Eriksson AE, Nature. 2002 Jun 13;417(6890):767-71. Epub 2002 Jun 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12050674 12050674]
[[Category: Hainzl, T.]]
[[Category: Hainzl, T.]]
[[Category: Huang, S.]]
[[Category: Huang, S.]]
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[[Category: Rna]]
[[Category: Rna]]
[[Category: Tetra-loop]]
[[Category: Tetra-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:09:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:50:43 2008''

Revision as of 01:50, 29 July 2008

Image:1z43.png

Template:STRUCTURE 1z43

Crystal structure of 7S.S SRP RNA of M. jannaschii

Template:ABSTRACT PUBMED 15928341

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural insights into SRP RNA: an induced fit mechanism for SRP assembly., Hainzl T, Huang S, Sauer-Eriksson AE, RNA. 2005 Jul;11(7):1043-50. Epub 2005 May 31. PMID:15928341

Structure of the SRP19 RNA complex and implications for signal recognition particle assembly., Hainzl T, Huang S, Sauer-Eriksson AE, Nature. 2002 Jun 13;417(6890):767-71. Epub 2002 Jun 5. PMID:12050674

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