1zh6

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[[Image:1zh6.gif|left|200px]]
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{{STRUCTURE_1zh6| PDB=1zh6 | SCENE= }}
{{STRUCTURE_1zh6| PDB=1zh6 | SCENE= }}
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'''Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine'''
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===Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine===
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==Overview==
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It has been recently shown that orthogonal tRNA/aminoacyl-tRNA synthetase pairs can be evolved to allow genetic incorporation of unnatural amino acids into proteins in both prokaryotes and eukaryotes. Here we describe the crystal structure of an evolved aminoacyl-tRNA synthetase that charges the unnatural amino acid p-acetylphenylalanine. Molecular recognition is due to altered hydrogen bonding and packing interactions with bound substrate that result from changes in both side-chain and backbone conformation.
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The line below this paragraph, {{ABSTRACT_PUBMED_16248607}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16248607 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16248607}}
==About this Structure==
==About this Structure==
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[[Category: Trna synthetase]]
[[Category: Trna synthetase]]
[[Category: Unnatural amino acid]]
[[Category: Unnatural amino acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:37:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:50:57 2008''

Revision as of 01:51, 29 July 2008

Image:1zh6.png

Template:STRUCTURE 1zh6

Crystal Structure of p-acetylphenylalanine-tRNA synthetase in complex with p-acetylphenylalanine

Template:ABSTRACT PUBMED 16248607

About this Structure

1ZH6 is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.

Reference

Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase., Turner JM, Graziano J, Spraggon G, Schultz PG, J Am Chem Soc. 2005 Nov 2;127(43):14976-7. PMID:16248607

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