2qfa

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{{STRUCTURE_2qfa| PDB=2qfa | SCENE= }}
{{STRUCTURE_2qfa| PDB=2qfa | SCENE= }}
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'''Crystal structure of a Survivin-Borealin-INCENP core complex'''
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===Crystal structure of a Survivin-Borealin-INCENP core complex===
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==Overview==
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The chromosomal passenger complex (CPC) is a key regulator of chromosome segregation and cytokinesis. CPC functions are connected to its localization. The complex first localizes to centromeres and later associates with the central spindle and midbody. Survivin, Borealin, and INCENP are the three components of the CPC that regulate the activity and localization of its enzymatic component, the kinase Aurora B. We determined the 1.4 A resolution crystal structure of the regulatory core of the CPC, revealing that Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. We used siRNA rescue experiments with structure-based mutants to explore the requirements for CPC localization. We show that the intertwined structural interactions of the core components lead to functional interdependence. Association of the core "passenger" proteins creates a single structural unit, whose composite molecular surface presents conserved residues essential for central spindle and midbody localization.
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(as it appears on PubMed at http://www.pubmed.gov), where 17956729 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17956729}}
==About this Structure==
==About this Structure==
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[[Category: Three-helical-bundle]]
[[Category: Three-helical-bundle]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:51:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:58:40 2008''

Revision as of 01:58, 29 July 2008

Image:2qfa.png

Template:STRUCTURE 2qfa

Crystal structure of a Survivin-Borealin-INCENP core complex

Template:ABSTRACT PUBMED 17956729

About this Structure

2QFA is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together., Jeyaprakash AA, Klein UR, Lindner D, Ebert J, Nigg EA, Conti E, Cell. 2007 Oct 19;131(2):271-85. PMID:17956729

Page seeded by OCA on Tue Jul 29 04:58:40 2008

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