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1obr

From Proteopedia

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{{STRUCTURE_1obr| PDB=1obr | SCENE= }}
{{STRUCTURE_1obr| PDB=1obr | SCENE= }}
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'''CARBOXYPEPTIDASE T'''
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===CARBOXYPEPTIDASE T===
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==Overview==
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The crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris has been determined at 0.235-nm resolution by X-ray diffraction. Carboxypeptidase T is a remote homologue of mammalian Zn-carboxypeptidases. In spite of the low degree of amino acid sequence identity, the three-dimensional structure of carboxypeptidase T is very similar to that of pancreatic carboxypeptidases A and B. The core of the protein molecule is formed by an eight-stranded mixed beta sheet. The active site is located at the C-edge of the central (parallel) part of the beta sheet. The structural organization of the active centre appears to be essentially the same in the three carboxypeptidases. Amino acid residues directly involved in catalysis and binding of the C-terminal carboxyl of a substrate are strictly conserved. This suggests that the catalytic mechanism proposed for the pancreatic enzymes is applicable to carboxypeptidase T and to the whole family of Zn-carboxypeptidases. Comparison of the amino acid replacements at the primary specificity pocket of carboxypeptidases A, B and T provides an explanation of the unusual 'A+B' type of specificity of carboxypeptidase T. Four calcium-binding sites localized in the crystal structure of carboxypeptidase T could account for the high thermostability of the protein.
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(as it appears on PubMed at http://www.pubmed.gov), where 1521526 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1521526}}
==About this Structure==
==About this Structure==
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[[Category: Carboxypeptidase]]
[[Category: Carboxypeptidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:38:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:58:58 2008''

Revision as of 01:58, 29 July 2008

Image:1obr.png

Template:STRUCTURE 1obr

CARBOXYPEPTIDASE T

Template:ABSTRACT PUBMED 1521526

About this Structure

1OBR is a Single protein structure of sequence from Thermoactinomyces vulgaris. Full crystallographic information is available from OCA.

Reference

Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris., Teplyakov A, Polyakov K, Obmolova G, Strokopytov B, Kuranova I, Osterman A, Grishin N, Smulevitch S, Zagnitko O, Galperina O, et al., Eur J Biochem. 1992 Sep 1;208(2):281-8. PMID:1521526

Page seeded by OCA on Tue Jul 29 04:58:58 2008

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