2ahm

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{{STRUCTURE_2ahm| PDB=2ahm | SCENE= }}
{{STRUCTURE_2ahm| PDB=2ahm | SCENE= }}
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'''Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer'''
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===Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer===
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==Overview==
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Coronavirus replication and transcription machinery involves multiple virus-encoded nonstructural proteins (nsp). We report the crystal structure of the hexadecameric nsp7-nsp8 supercomplex from the severe acute respiratory syndrome coronavirus at 2.4-angstroms resolution. nsp8 has a novel 'golf-club' fold with two conformations. The supercomplex is a unique hollow, cylinder-like structure assembled from eight copies of nsp8 and held tightly together by eight copies of nsp7. With an internal diameter of approximately 30 angstroms, the central channel has dimensions and positive electrostatic properties favorable for nucleic acid binding, implying that its role is to confer processivity on RNA-dependent RNA polymerase.
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(as it appears on PubMed at http://www.pubmed.gov), where 16228002 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16228002}}
==About this Structure==
==About this Structure==
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[[Category: Sars-cov]]
[[Category: Sars-cov]]
[[Category: Super-complex]]
[[Category: Super-complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:03:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:00:06 2008''

Revision as of 02:00, 29 July 2008

Image:2ahm.png

Template:STRUCTURE 2ahm

Crystal structure of SARS-CoV super complex of non-structural proteins: the hexadecamer

Template:ABSTRACT PUBMED 16228002

About this Structure

2AHM is a Protein complex structure of sequences from Human sars coronavirus. Full crystallographic information is available from OCA.

Reference

Insights into SARS-CoV transcription and replication from the structure of the nsp7-nsp8 hexadecamer., Zhai Y, Sun F, Li X, Pang H, Xu X, Bartlam M, Rao Z, Nat Struct Mol Biol. 2005 Nov;12(11):980-6. PMID:16228002

Page seeded by OCA on Tue Jul 29 05:00:06 2008

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