1wdu

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{{STRUCTURE_1wdu| PDB=1wdu | SCENE= }}
{{STRUCTURE_1wdu| PDB=1wdu | SCENE= }}
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'''Endonuclease domain of TRAS1, a telomere-specific non-LTR retrotransposon'''
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===Endonuclease domain of TRAS1, a telomere-specific non-LTR retrotransposon===
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==Overview==
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The telomere-specific long interspersed nuclear element, TRAS1, encodes an endonuclease domain, TRAS1-EN, which specifically cleaves the telomeric repeat targets (TTAGG)n of insects and (TTAGGG)n of vertebrates. To elucidate the sequence-specific recognition properties of TRAS1-EN, we determined the crystal structure at 2.4-A resolution. TRAS1-EN has a four-layered alpha/beta sandwich structure; its topology is similar to apurinic/apyrimidinic endonucleases, but the beta-hairpin (beta10-beta11) at the edge of the DNA-binding surface makes an extra loop that distinguishes TRAS1-EN from cellular apurinic/apyrimidinic endonucleases. A protein-DNA complex model suggests that the beta10-beta11 hairpin fits into the minor groove, enabling interaction with the telomeric repeats. Mutational studies of TRAS1-EN also indicated that the Asp-130 and beta10-beta11 hairpin structure are involved in specific recognition of telomeric repeats.
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{{ABSTRACT_PUBMED_15247245}}
==About this Structure==
==About this Structure==
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[[Category: Mizuno, H.]]
[[Category: Mizuno, H.]]
[[Category: Four-layered alpha/beta sandwich]]
[[Category: Four-layered alpha/beta sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:30:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:02:06 2008''

Revision as of 02:02, 29 July 2008

Image:1wdu.png

Template:STRUCTURE 1wdu

Endonuclease domain of TRAS1, a telomere-specific non-LTR retrotransposon

Template:ABSTRACT PUBMED 15247245

About this Structure

1WDU is a Single protein structure of sequence from Bombyx mori. Full crystallographic information is available from OCA.

Reference

Crystal structure of the endonuclease domain encoded by the telomere-specific long interspersed nuclear element, TRAS1., Maita N, Anzai T, Aoyagi H, Mizuno H, Fujiwara H, J Biol Chem. 2004 Sep 24;279(39):41067-76. Epub 2004 Jul 9. PMID:15247245

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