1w4r

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[[Image:1w4r.gif|left|200px]]
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{{STRUCTURE_1w4r| PDB=1w4r | SCENE= }}
{{STRUCTURE_1w4r| PDB=1w4r | SCENE= }}
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'''STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP'''
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===STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP===
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==Overview==
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The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications.
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(as it appears on PubMed at http://www.pubmed.gov), where 15733844 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15733844}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Type ii]]
[[Category: Type ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:09:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:05:24 2008''

Revision as of 02:05, 29 July 2008

Image:1w4r.png

Template:STRUCTURE 1w4r

STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP

Template:ABSTRACT PUBMED 15733844

About this Structure

1W4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844

Page seeded by OCA on Tue Jul 29 05:05:24 2008

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