2rlu

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[[Image:2rlu.jpg|left|200px]]
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[[Image:2rlu.png|left|200px]]
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{{STRUCTURE_2rlu| PDB=2rlu | SCENE= }}
{{STRUCTURE_2rlu| PDB=2rlu | SCENE= }}
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'''The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB'''
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===The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB===
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==Overview==
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Incorporation of the amino acid selenocysteine into a growing protein chain involves the interaction between a hairpin in the mRNA termed the selenocysteine insertion sequence (SECIS) and the special elongation factor SelB. Here we present the structure of the SECIS from the thermophilic organism Moorella thermoacetica (SECIS-MT) determined using nuclear magnetic resonance (NMR) spectroscopy. The SECIS-MT hairpin structure contains a pentaloop with the first and fourth nucleotides of the loop forming a noncanonical GC base pair; the fifth loop nucleotide is bulged out and unstructured. The G and U in positions two and three are on opposite sides of the loop and solvent exposed. The backbone resonances of the SECIS-binding domain from the M. thermoacetica SelB protein were assigned, and the degree of chemical shift perturbations that occur upon SECIS binding were mapped onto the structure of the complex. We demonstrate that a region in the third winged-helix domain of SelB, not previously implicated in binding, is affected by SECIS binding.
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(as it appears on PubMed at http://www.pubmed.gov), where 17901155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17901155}}
==About this Structure==
==About this Structure==
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2RLU is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA].
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2RLU is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RLU OCA].
==Reference==
==Reference==
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[[Category: Selb]]
[[Category: Selb]]
[[Category: Selenocysteine]]
[[Category: Selenocysteine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:08:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:06:30 2008''

Revision as of 02:06, 29 July 2008

Image:2rlu.png

Template:STRUCTURE 2rlu

The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB

Template:ABSTRACT PUBMED 17901155

About this Structure

2RLU is a Single protein structure. Full experimental information is available from OCA.

Reference

The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB., Beribisky AV, Tavares TJ, Amborski AN, Motamed M, Johnson AE, Mark TL, Johnson PE, RNA. 2007 Nov;13(11):1948-56. Epub 2007 Sep 27. PMID:17901155

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