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| | {{STRUCTURE_2hy9| PDB=2hy9 | SCENE= }} | | {{STRUCTURE_2hy9| PDB=2hy9 | SCENE= }} |
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| - | '''solution structure of the human telomeric quadruplex'''
| + | ===solution structure of the human telomeric quadruplex=== |
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| - | ==Overview==
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| - | We report the NMR solution structure of the intramolecular G-quadruplex formed in human telomeric DNA in K(+). The hybrid-type telomeric G-quadruplex consists of three G-tetrads linked with mixed parallel-antiparallel G-strands, with the bottom two G-tetrads having the same G-arrangement (anti:anti:syn:anti) and the top G-tetrad having the reversed G-arrangement (syn:syn:anti:syn). The three TTA loop segments adopt different conformations, with the first TTA assuming a double-chain-reversal loop conformation, and the second and third TTA assuming lateral loop conformations. The NMR structure is very well defined, including the three TTA loops and the two flanking sequences at 5'- and 3'-ends. Our study indicates that the three loop regions interact with the core G-tetrads in a specific way that defines and stabilizes the unique human telomeric G-quadruplex structure in K(+). Significantly, a novel adenine triple platform is formed with three naturally occurring adenine residues, A21, A3 and A9, capping the top tetrad of the hybrid-type telomeric G-quadruplex. This adenine triple is likely to play an important role in the formation of a stable human telomeric G-quadruplex structure in K(+). The unique human telomeric G-quadruplex structure formed in K(+) suggests that it can be specifically targeted for anticancer drug design.
| + | The line below this paragraph, {{ABSTRACT_PUBMED_17395643}}, adds the Publication Abstract to the page |
| | + | (as it appears on PubMed at http://www.pubmed.gov), where 17395643 is the PubMed ID number. |
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| | + | {{ABSTRACT_PUBMED_17395643}} |
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| | ==About this Structure== | | ==About this Structure== |
| - | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA]. | + | Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA]. |
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| | ==Reference== | | ==Reference== |
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| | [[Category: Yang, D.]] | | [[Category: Yang, D.]] |
| | [[Category: G-quadruplex]] | | [[Category: G-quadruplex]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:51:43 2008'' | + | |
| | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:11:34 2008'' |
Revision as of 02:11, 29 July 2008
Template:STRUCTURE 2hy9
solution structure of the human telomeric quadruplex
Template:ABSTRACT PUBMED 17395643
About this Structure
Full experimental information is available from OCA.
Reference
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:17395643
Page seeded by OCA on Tue Jul 29 05:11:34 2008
