1qxo

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[[Image:1qxo.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_1qxo| PDB=1qxo | SCENE= }}
{{STRUCTURE_1qxo| PDB=1qxo | SCENE= }}
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'''Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP'''
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===Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP===
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==Overview==
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The crystal structure of chorismate synthase (CS) from Streptococcus pneumoniae has been solved to 2.0 A resolution in the presence of flavin mononucleotide (FMN) and the substrate 5-enolpyruvyl-3-shikimate phosphate (EPSP). CS catalyses the final step of the shikimate pathway and is a potential therapeutic target for the rational design of novel antibacterials, antifungals, antiprotozoals, and herbicides. CS is a tetramer with the monomer possessing a novel beta-alpha-beta fold. The interactions between the enzyme, cofactor, and substrate reveal the structural reasons underlying the unique catalytic mechanism and identify the amino acids involved. This structure provides the essential initial information necessary for the generation of novel anti-infective compounds by a structure-guided medicinal chemistry approach.
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(as it appears on PubMed at http://www.pubmed.gov), where 14656434 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14656434}}
==About this Structure==
==About this Structure==
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[[Category: Flavoprotein]]
[[Category: Flavoprotein]]
[[Category: Shikimate]]
[[Category: Shikimate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:49:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:13:03 2008''

Revision as of 02:13, 29 July 2008

Image:1qxo.png

Template:STRUCTURE 1qxo

Crystal structure of Chorismate synthase complexed with oxidized FMN and EPSP

Template:ABSTRACT PUBMED 14656434

About this Structure

1QXO is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

The structure of chorismate synthase reveals a novel flavin binding site fundamental to a unique chemical reaction., Maclean J, Ali S, Structure. 2003 Dec;11(12):1499-511. PMID:14656434

Page seeded by OCA on Tue Jul 29 05:13:03 2008

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