2uyd

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{{STRUCTURE_2uyd| PDB=2uyd | SCENE= }}
{{STRUCTURE_2uyd| PDB=2uyd | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE SMHASA MUTANT H83A'''
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===CRYSTAL STRUCTURE OF THE SMHASA MUTANT H83A===
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==Overview==
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Heme carrier HasA has a unique type of histidine/tyrosine heme iron ligation in which the iron ion is in a thermally driven two spin state equilibrium. We recently suggested that the H-bonding between Y75 and the invariantly conserved residue H83 modulates the strength of the Fe-Y75 bond. To unravel the role of H83, we characterize the iron ligation and the electronic properties of both wild type and H83A mutant by a variety of spectroscopic techniques. While H83 in wild type modulates the strength of the Tyr-iron bond, its removal causes detachment of the tyrosine ligand, thus giving rise to a series of pH dependent equilibria among species with different axial ligation. The five coordinated species detected at physiological pH may represent a possible intermediate of the heme transfer mechanism to the receptor.
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(as it appears on PubMed at http://www.pubmed.gov), where 18162469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18162469}}
==About this Structure==
==About this Structure==
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[[Category: Metal-binding]]
[[Category: Metal-binding]]
[[Category: Metal-binding protein]]
[[Category: Metal-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 17:48:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:13:16 2008''

Revision as of 02:13, 29 July 2008

Image:2uyd.png

Template:STRUCTURE 2uyd

CRYSTAL STRUCTURE OF THE SMHASA MUTANT H83A

Template:ABSTRACT PUBMED 18162469

About this Structure

2UYD is a Single protein structure of sequence from Serratia marcescens. Full crystallographic information is available from OCA.

Reference

Deciphering the structural role of histidine 83 for heme binding in hemophore HasA., Caillet-Saguy C, Turano P, Piccioli M, Lukat-Rodgers GS, Czjzek M, Guigliarelli B, Izadi-Pruneyre N, Rodgers KR, Delepierre M, Lecroisey A, J Biol Chem. 2007 Dec 27;. PMID:18162469

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