1r77

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{{STRUCTURE_1r77| PDB=1r77 | SCENE= }}
{{STRUCTURE_1r77| PDB=1r77 | SCENE= }}
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'''Crystal structure of the cell wall targeting domain of peptidylglycan hydrolase ALE-1'''
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===Crystal structure of the cell wall targeting domain of peptidylglycan hydrolase ALE-1===
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==Overview==
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ALE-1, a homologue of lysostaphin, is a peptidoglycan hydrolase that specifically lyses Staphylococcus aureus cell walls by cleaving the pentaglycine linkage between the peptidoglycan chains. Binding of ALE-1 to S. aureus cells through its C-terminal 92 residues, known as the targeting domain, is functionally important for staphylolytic activity. The ALE-1-targeting domain belongs to the SH3b domain family, the prokaryotic counterpart of the eukaryotic SH3 domains. The 1.75 angstroms crystal structure of the targeting domain shows an all-beta fold similar to typical SH3s but with unique features. The structure reveals patches of conserved residues among orthologous targeting domains, forming surface regions that can potentially interact with some common features of the Gram-positive cell wall. ALE-1-targeting domain binding studies employing various bacterial peptidoglycans demonstrate that the length of the interpeptide bridge, as well as the amino acid composition of the peptide, confers the maximum binding of the targeting domain to the staphylococcal peptidoglycan. Truncation of the highly conserved first 9 N-terminal residues results in loss of specificity to S. aureus cell wall-targeting, suggesting that these residues confer specificity to S. aureus cell wall.
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(as it appears on PubMed at http://www.pubmed.gov), where 16257954 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16257954}}
==About this Structure==
==About this Structure==
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[[Category: Peptidoglycan hydrolase]]
[[Category: Peptidoglycan hydrolase]]
[[Category: Sh3b domain]]
[[Category: Sh3b domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:10:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:16:44 2008''

Revision as of 02:16, 29 July 2008

Image:1r77.png

Template:STRUCTURE 1r77

Crystal structure of the cell wall targeting domain of peptidylglycan hydrolase ALE-1

Template:ABSTRACT PUBMED 16257954

About this Structure

1R77 is a Single protein structure of sequence from Staphylococcus capitis. Full crystallographic information is available from OCA.

Reference

Cell wall-targeting domain of glycylglycine endopeptidase distinguishes among peptidoglycan cross-bridges., Lu JZ, Fujiwara T, Komatsuzawa H, Sugai M, Sakon J, J Biol Chem. 2006 Jan 6;281(1):549-58. Epub 2005 Oct 28. PMID:16257954

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