1t8z

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{{STRUCTURE_1t8z| PDB=1t8z | SCENE= }}
{{STRUCTURE_1t8z| PDB=1t8z | SCENE= }}
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'''Atomic Structure of A Novel Tryptophan-Zipper Pentamer'''
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===Atomic Structure of A Novel Tryptophan-Zipper Pentamer===
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==Overview==
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Coiled-coil motifs are ubiquitous mediators of specific protein-protein interactions through the formation of interlocking hydrophobic seams between alpha-helical chains. Residues that form these seams occur at the first (a) and fourth (d) positions of a characteristic 7-aa repeat and are primarily aliphatic. The potential of aromatic residues to promote helix association in a coiled coil was explored by engineering a "Trp-zipper" protein with Trp residues at all 14 a and d positions. The protein forms a discrete, stable, alpha-helical pentamer in water at physiological pH. Its 1.45-A crystal structure reveals a parallel, five-stranded coiled coil, a previously uncharacterized type of "knobs-into-holes" packing interaction between interfacial Trp side chains, and an unusual approximately 8-A-diameter axial channel lined with indole rings that is filled with polyethylene glycol 400 and water and sulfate ion molecules. The engineered Trp-zipper pentamer enlarges current views of coiled-coil assembly, molecular recognition, and protein engineering, and may serve as a soluble model for membrane ion channels.
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{{ABSTRACT_PUBMED_15520380}}
==About this Structure==
==About this Structure==
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[[Category: Protein folding]]
[[Category: Protein folding]]
[[Category: Tryptophan-zipper]]
[[Category: Tryptophan-zipper]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:41:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:20:59 2008''

Revision as of 02:21, 29 July 2008

Image:1t8z.png

Template:STRUCTURE 1t8z

Atomic Structure of A Novel Tryptophan-Zipper Pentamer

Template:ABSTRACT PUBMED 15520380

About this Structure

1T8Z is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Atomic structure of a tryptophan-zipper pentamer., Liu J, Yong W, Deng Y, Kallenbach NR, Lu M, Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16156-61. Epub 2004 Nov 1. PMID:15520380

Page seeded by OCA on Tue Jul 29 05:20:59 2008

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