1rtb

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[[Image:1rtb.jpg|left|200px]]
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{{STRUCTURE_1rtb| PDB=1rtb | SCENE= }}
{{STRUCTURE_1rtb| PDB=1rtb | SCENE= }}
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'''CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A'''
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===CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A===
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==Overview==
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The crystal structure of ribonuclease A with bound thymidylic acid tetramer is reported at 2.5-A resolution. The diffusion of the tetramer into native orthorhombic crystals of the ribonuclease allows for the formation of a structurally stable complex where the single-stranded nucleic acid enters and leaves the enzyme's catalytic region in a persistent 5'-3' direction. The binding of the tetramer to the enzyme's surface is facilitated and mediated by electrostatic interactions between basic protein residues and nucleotide phosphates. Two pyrimidine nucleotides are bound to the enzyme's active site in a manner similar to that observed for other complexes between ribonuclease A and nucleic acid oligomers.
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(as it appears on PubMed at http://www.pubmed.gov), where 1429575 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1429575}}
==About this Structure==
==About this Structure==
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[[Category: Birdsall, D L.]]
[[Category: Birdsall, D L.]]
[[Category: McPherson, A.]]
[[Category: McPherson, A.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:52:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:24:52 2008''

Revision as of 02:24, 29 July 2008

Image:1rtb.png

Template:STRUCTURE 1rtb

CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A

Template:ABSTRACT PUBMED 1429575

About this Structure

1RTB is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A., Birdsall DL, McPherson A, J Biol Chem. 1992 Nov 5;267(31):22230-6. PMID:1429575

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