1v00
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(New page: 200px<br /> <applet load="1v00" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v00, resolution 1.70Å" /> '''ERYTHRINA CRISTAGAL...)
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Revision as of 18:38, 29 October 2007
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ERYTHRINA CRISTAGALLI LECTIN
Overview
Erythrina cristagalli lectin (ECL) is a galactose-specific legume lectin., Although its biological function in the legume is unknown, ECL exhibits, hemagglutinating activity in vitro and is mitogenic for T lymphocytes. In, addition, it has been recently shown that ECL forms a novel conjugate when, coupled to a catalytically active derivative of the type A neurotoxin from, Clostridium botulinum, thus providing a therapeutic potential. ECL is, biologically active as a dimer in which each protomer contains a, functional carbohydrate-combining site. The crystal structure of native, ECL was recently reported in complex with lactose and 2'-fucosyllactose., ECL protomers adopt the legume lectin fold but form non-canonical dimers, via the handshake motif as was previously observed for Erythrina, ... [(full description)]
About this Structure
1V00 is a [Single protein] structure of sequence from [Erythrina crista-galli] with LAT, MN and CA as [ligands]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:15201215
Page seeded by OCA on Mon Oct 29 20:43:06 2007
