1q4q

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[[Image:1q4q.gif|left|200px]]
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{{Seed}}
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[[Image:1q4q.png|left|200px]]
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{{STRUCTURE_1q4q| PDB=1q4q | SCENE= }}
{{STRUCTURE_1q4q| PDB=1q4q | SCENE= }}
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'''Crystal structure of a DIAP1-Dronc complex'''
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===Crystal structure of a DIAP1-Dronc complex===
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==Overview==
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The inhibitor of apoptosis protein DIAP1 inhibits Dronc-dependent cell death by ubiquitinating Dronc. The pro-death proteins Reaper, Hid and Grim (RHG) promote apoptosis by antagonizing DIAP1 function. Here we report the structural basis of Dronc recognition by DIAP1 as well as a novel mechanism by which the RHG proteins remove DIAP1-mediated downregulation of Dronc. Biochemical and structural analyses revealed that the second BIR (BIR2) domain of DIAP1 recognizes a 12-residue sequence in Dronc. This recognition is essential for DIAP1 binding to Dronc, and for targeting Dronc for ubiquitination. Notably, the Dronc-binding surface on BIR2 coincides with that required for binding to the N termini of the RHG proteins, which competitively eliminate DIAP1-mediated ubiquitination of Dronc. These observations reveal the molecular mechanisms of how DIAP1 recognizes Dronc, and more importantly, how the RHG proteins remove DIAP1-mediated ubiquitination of Dronc.
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The line below this paragraph, {{ABSTRACT_PUBMED_14517550}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14517550 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14517550}}
==About this Structure==
==About this Structure==
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[[Category: Mechanism]]
[[Category: Mechanism]]
[[Category: Ubiquitination]]
[[Category: Ubiquitination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:51:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:27:15 2008''

Revision as of 02:27, 29 July 2008

Image:1q4q.png

Template:STRUCTURE 1q4q

Crystal structure of a DIAP1-Dronc complex

Template:ABSTRACT PUBMED 14517550

About this Structure

1Q4Q is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination., Chai J, Yan N, Huh JR, Wu JW, Li W, Hay BA, Shi Y, Nat Struct Biol. 2003 Nov;10(11):892-8. Epub 2003 Sep 28. PMID:14517550

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