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2ng1

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{{STRUCTURE_2ng1| PDB=2ng1 | SCENE= }}
{{STRUCTURE_2ng1| PDB=2ng1 | SCENE= }}
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'''N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS'''
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===N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS===
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==Overview==
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Ffh is a component of a bacterial ribonucleoprotein complex homologous to the signal recognition particle (SRP) of eukaryotes. It comprises three domains that mediate both binding to the hydrophobic signal sequence of the nascent polypeptide and the GTP-dependent interaction of Ffh with a structurally homologous GTPase of the SRP receptor. The X-ray structures of the two-domain 'NG' GTPase of Ffh in complex with Mg2+GDP and GDP have been determined at 2.0 A resolution. The structures explain the low nucleotide affinity of Ffh and locate two regions of structural mobility at opposite sides of the nucleotide-binding site. One of these regions includes highly conserved sequence motifs that presumably contribute to the structural trigger signaling the GTP-bound state. The other includes the highly conserved interface between the N and G domains, and supports the hypothesis that the N domain regulates or signals the nucleotide occupancy of the G domain.
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(as it appears on PubMed at http://www.pubmed.gov), where 10426959 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10426959}}
==About this Structure==
==About this Structure==
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[[Category: Signal recognition particle]]
[[Category: Signal recognition particle]]
[[Category: Srp]]
[[Category: Srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:35:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:28:01 2008''

Revision as of 02:28, 29 July 2008

Image:2ng1.png

Template:STRUCTURE 2ng1

N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS

Template:ABSTRACT PUBMED 10426959

About this Structure

2NG1 is a Single protein structure of sequence from Thermus aquaticus. Full crystallographic information is available from OCA.

Reference

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP., Freymann DM, Keenan RJ, Stroud RM, Walter P, Nat Struct Biol. 1999 Aug;6(8):793-801. PMID:10426959

Page seeded by OCA on Tue Jul 29 05:28:01 2008

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