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1n96

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{{STRUCTURE_1n96| PDB=1n96 | SCENE= }}
{{STRUCTURE_1n96| PDB=1n96 | SCENE= }}
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'''DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)'''
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===DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)===
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==Overview==
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The solution structure of a cyclic oligonucleotide d&lt;pCGCTCATT&gt; has been determined by two-dimensional NMR spectroscopy and restrained molecular dynamics. Under the appropriate experimental conditions, this molecule self-associates, forming a symmetric dimer stabilized by four intermolecular Watson-Crick base pairs. The resulting four-stranded structure consists of two G:C:A:T tetrads, formed by facing the minor groove side of the Watson-Crick base-pairs. Most probably, the association of the base-pairs is stabilized by coordinating a Na(+) cation. This is the first time that this novel G:C:A:T tetrad has been found in an oligonucleotide structure. This observation increases considerably the number of sequences that may adopt a four-stranded architecture. Overall, the three-dimensional structure is similar to those observed previously in other quadruplexes formed by minor groove alignment of Watson-Crick base pairs. This resemblance strongly suggests that we may be observing a general motif for DNA-DNA recognition.
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(as it appears on PubMed at http://www.pubmed.gov), where 12733903 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12733903}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N96 OCA].
==Reference==
==Reference==
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[[Category: Quadruplex]]
[[Category: Quadruplex]]
[[Category: Unusual dna]]
[[Category: Unusual dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:15:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:28:37 2008''

Revision as of 02:28, 29 July 2008

Image:1n96.png

Template:STRUCTURE 1n96

DIMERIC SOLUTION STRUCTURE OF THE CYCLIC OCTAMER CD(CGCTCATT)

Template:ABSTRACT PUBMED 12733903

About this Structure

Full experimental information is available from OCA.

Reference

Four-stranded DNA structure stabilized by a novel G:C:A:T tetrad., Escaja N, Gelpi JL, Orozco M, Rico M, Pedroso E, Gonzalez C, J Am Chem Soc. 2003 May 14;125(19):5654-62. PMID:12733903

Page seeded by OCA on Tue Jul 29 05:28:37 2008

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