1sop

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{{STRUCTURE_1sop| PDB=1sop | SCENE= }}
{{STRUCTURE_1sop| PDB=1sop | SCENE= }}
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'''C-terminal cystine-rich domain of Minicollagen-I from Hydra'''
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===C-terminal cystine-rich domain of Minicollagen-I from Hydra===
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==Overview==
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The minicollagens found in the nematocysts of Hydra constitute a family of invertebrate collagens with unusual properties. They share a common modular architecture with a central collagen sequence ranging from 14 to 16 Gly-X-Y repeats flanked by polyproline/hydroxyproline stretches and short terminal domains that show a conserved cysteine pattern (CXXXCXXXCXXX-CXXXCC). The minicollagen cysteine-rich domains are believed to function in a switch of the disulfide connectivity from intra- to intermolecular bonds during maturation of the capsule wall. The solution structure of the C-terminal fragment including a minicollagen cysteine-rich domain of minicollagen-1 was determined in two independent groups by 1H NMR. The corresponding peptide comprising the last 24 residues of the molecule was produced synthetically and refolded by oxidation under low protein concentrations. Both presented structures are identical in their fold and disulfide connections (Cys2-Cys18, Cys6-Cys14, and Cys10-Cys19) revealing a robust structural motif that is supposed to serve as the polymerization module of the nematocyst capsule.
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The line below this paragraph, {{ABSTRACT_PUBMED_15123641}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15123641 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15123641}}
==About this Structure==
==About this Structure==
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1SOP is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOP OCA].
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1SOP is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOP OCA].
==Reference==
==Reference==
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[[Category: Renner, C.]]
[[Category: Renner, C.]]
[[Category: Collagen oxidative refolding]]
[[Category: Collagen oxidative refolding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:57:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:29:12 2008''

Revision as of 02:29, 29 July 2008

Image:1sop.png

Template:STRUCTURE 1sop

C-terminal cystine-rich domain of Minicollagen-I from Hydra

Template:ABSTRACT PUBMED 15123641

About this Structure

1SOP is a Single protein structure. Full experimental information is available from OCA.

Reference

The structure of the Cys-rich terminal domain of Hydra minicollagen, which is involved in disulfide networks of the nematocyst wall., Pokidysheva E, Milbradt AG, Meier S, Renner C, Haussinger D, Bachinger HP, Moroder L, Grzesiek S, Holstein TW, Ozbek S, Engel J, J Biol Chem. 2004 Jul 16;279(29):30395-401. Epub 2004 May 3. PMID:15123641

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