2hvd

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{{STRUCTURE_2hvd| PDB=2hvd | SCENE= }}
{{STRUCTURE_2hvd| PDB=2hvd | SCENE= }}
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'''Human nucleoside diphosphate kinase A complexed with ADP'''
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===Human nucleoside diphosphate kinase A complexed with ADP===
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==Overview==
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Nm23 was the first metastasis suppressor gene identified. This gene encodes a NDP kinase that also exhibits other properties like histidine protein kinase and interactions with proteins and DNA. The S120G mutant of NDPK-A has been identified in aggressive neuroblastomas and has been found to reduce the metastasis suppressor effect of Nm23. In order to understand the differences between the wild type and the S120G mutant, we have determined the structure of both mutant and wild type NDPK-A in complex with ADP. Our results reveal that there are no significant changes between the two enzyme versions even in the surroundings of the catalytic histidine that is required for NDP kinase activity. This suggests that the S120G mutation may affect an other protein property than NDP kinase activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16944299 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16944299}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP., Giraud MF, Georgescauld F, Lascu I, Dautant A, J Bioenerg Biomembr. 2006 Aug;38(3-4):261-4. Epub 2006 Sep 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16944299 16944299]
Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP., Giraud MF, Georgescauld F, Lascu I, Dautant A, J Bioenerg Biomembr. 2006 Aug;38(3-4):261-4. Epub 2006 Sep 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16944299 16944299]
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Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor., Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW, Proteins. 2002 Feb 15;46(3):340-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11835509 11835509]
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Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases., Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J, J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12972261 12972261]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nucleoside-diphosphate kinase]]
[[Category: Nucleoside-diphosphate kinase]]
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[[Category: Lascu, I.]]
[[Category: Lascu, I.]]
[[Category: Complex adp]]
[[Category: Complex adp]]
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Revision as of 02:29, 29 July 2008

Image:2hvd.png

Template:STRUCTURE 2hvd

Human nucleoside diphosphate kinase A complexed with ADP

Template:ABSTRACT PUBMED 16944299

About this Structure

2HVD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP., Giraud MF, Georgescauld F, Lascu I, Dautant A, J Bioenerg Biomembr. 2006 Aug;38(3-4):261-4. Epub 2006 Sep 1. PMID:16944299

Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor., Min K, Song HK, Chang C, Kim SY, Lee KJ, Suh SW, Proteins. 2002 Feb 15;46(3):340-2. PMID:11835509

Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases., Chen Y, Gallois-Montbrun S, Schneider B, Veron M, Morera S, Deville-Bonne D, Janin J, J Mol Biol. 2003 Sep 26;332(4):915-26. PMID:12972261

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