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2o5n

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{{STRUCTURE_2o5n| PDB=2o5n | SCENE= }}
{{STRUCTURE_2o5n| PDB=2o5n | SCENE= }}
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'''Crystal structure of a Viral Glycoprotein'''
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===Crystal structure of a Viral Glycoprotein===
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==Overview==
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Mouse cytomegalovirus (MCMV), a beta-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted major histocompatibility complex, class I (MHC-I) structure. Functions attributed to some family members include down-regulation of host MHC-I (m152) and NKG2D ligands (m145, m152, and m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical, and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require beta2m or peptide and is expressed at the surface of MCMV-infected cells. Its 2.4-A crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended N terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family.
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(as it appears on PubMed at http://www.pubmed.gov), where 17897947 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17897947}}
==About this Structure==
==About this Structure==
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[[Category: Mouse cytomegalovirus]]
[[Category: Mouse cytomegalovirus]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:21:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:30:46 2008''

Revision as of 02:30, 29 July 2008

Image:2o5n.png

Template:STRUCTURE 2o5n

Crystal structure of a Viral Glycoprotein

Template:ABSTRACT PUBMED 17897947

About this Structure

Full crystallographic information is available from OCA.

Reference

Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153., Mans J, Natarajan K, Balbo A, Schuck P, Eikel D, Hess S, Robinson H, Simic H, Jonjic S, Tiemessen CT, Margulies DH, J Biol Chem. 2007 Nov 30;282(48):35247-58. Epub 2007 Sep 26. PMID:17897947

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