1ogo

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[[Image:1ogo.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1ogo| PDB=1ogo | SCENE= }}
{{STRUCTURE_1ogo| PDB=1ogo | SCENE= }}
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'''DEX49A FROM PENICILLIUM MINIOLUTEUM COMPLEX WITH ISOMALTOSE'''
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===DEX49A FROM PENICILLIUM MINIOLUTEUM COMPLEX WITH ISOMALTOSE===
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==Overview==
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Dextranase catalyzes the hydrolysis of the alpha-1,6-glycosidic linkage in dextran polymers. The structure of dextranase, Dex49A, from Penicillium minioluteum was solved in the apo-enzyme and product-bound forms. The main domain of the enzyme is a right-handed parallel beta helix, which is connected to a beta sandwich domain at the N terminus. In the structure of the product complex, isomaltose was found to bind in a crevice on the surface of the enzyme. The glycosidic oxygen of the glucose unit in subsite +1 forms a hydrogen bond to the suggested catalytic acid, Asp395. By NMR spectroscopy the reaction course was shown to occur with net inversion at the anomeric carbon, implying a single displacement mechanism. Both Asp376 and Asp396 are suitably positioned to activate the water molecule that performs the nucleophilic attack. A new clan that links glycoside hydrolase families 28 and 49 is suggested.
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(as it appears on PubMed at http://www.pubmed.gov), where 12962629 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12962629}}
==About this Structure==
==About this Structure==
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[[Category: Glycosidase]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:49:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:33:15 2008''

Revision as of 02:33, 29 July 2008

Image:1ogo.png

Template:STRUCTURE 1ogo

DEX49A FROM PENICILLIUM MINIOLUTEUM COMPLEX WITH ISOMALTOSE

Template:ABSTRACT PUBMED 12962629

About this Structure

1OGO is a Single protein structure of sequence from Penicillium minioluteum. Full crystallographic information is available from OCA.

Reference

Dextranase from Penicillium minioluteum: reaction course, crystal structure, and product complex., Larsson AM, Andersson R, Stahlberg J, Kenne L, Jones TA, Structure. 2003 Sep;11(9):1111-21. PMID:12962629

Page seeded by OCA on Tue Jul 29 05:33:15 2008

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