2otq

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{{STRUCTURE_2otq| PDB=2otq | SCENE= }}
{{STRUCTURE_2otq| PDB=2otq | SCENE= }}
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'''Structure of the antimicrobial peptide cyclo(RRWFWR) bound to DPC micelles'''
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===Structure of the antimicrobial peptide cyclo(RRWFWR) bound to DPC micelles===
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==Overview==
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New antimicrobial compounds are of major importance because of the growing problem of bacterial resistance. In this context, antimicrobial peptides have received a lot of attention. Their mechanism of action, however, is often obscure. Here, the structures of two cyclic, antimicrobial peptides from the family of arginine- and tryptophan-rich peptides determined in a membrane-mimicking environment are described. The sequence of the peptides has been obtained from a cyclic parent peptide by scrambling the amino acids. While the activity of the peptides is similar to that of the parent peptide, the structures are not. The peptides do, however, all adopt an amphiphilic structure. A comparison between the structures helps to define the requirements for the activity of these peptides. Copyright (c) 2007 European Peptide Society and John Wiley &amp; Sons, Ltd.
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(as it appears on PubMed at http://www.pubmed.gov), where 17985394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17985394}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTQ OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTQ OCA].
==Reference==
==Reference==
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[[Category: Antimicrobial protein]]
[[Category: Antimicrobial protein]]
[[Category: Cationic antimicrobial peptide]]
[[Category: Cationic antimicrobial peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:38:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:34:09 2008''

Revision as of 02:34, 29 July 2008

Image:2otq.png

Template:STRUCTURE 2otq

Structure of the antimicrobial peptide cyclo(RRWFWR) bound to DPC micelles

Template:ABSTRACT PUBMED 17985394

About this Structure

Full experimental information is available from OCA.

Reference

Structures of cyclic, antimicrobial peptides in a membrane-mimicking environment define requirements for activity., Appelt C, Wessolowski A, Dathe M, Schmieder P, J Pept Sci. 2007 Nov 6;. PMID:17985394

Page seeded by OCA on Tue Jul 29 05:34:09 2008

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