1vsr

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{{STRUCTURE_1vsr| PDB=1vsr | SCENE= }}
{{STRUCTURE_1vsr| PDB=1vsr | SCENE= }}
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'''VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI'''
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===VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI===
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==Overview==
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Vsr endonuclease plays a crucial role in the repair of TG mismatched base pairs, which are generated by the spontaneous degradation of methylated cytidines; Vsr recognizes the mismatched base pair and cleaves the phosphate backbone 5' to the thymidine. We have determined the crystal structure of a truncated form of this endonuclease at 1.8 A resolution. The protein contains one structural zinc-binding module. Unexpectedly, its overall topology resembles members of the type II restriction endonuclease family. Subsequent mutational and biochemical analyses showed that certain elements in the catalytic site are also conserved. However, the identification of a critical histidine and evidence of an active site metal-binding coordination that is novel to endonucleases indicate a distinct catalytic mechanism.
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{{ABSTRACT_PUBMED_10360178}}
==About this Structure==
==About this Structure==
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[[Category: Endonuclease]]
[[Category: Endonuclease]]
[[Category: Mismatch recognition]]
[[Category: Mismatch recognition]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:52:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:40:44 2008''

Revision as of 02:40, 29 July 2008

Image:1vsr.png

Template:STRUCTURE 1vsr

VERY SHORT PATCH REPAIR (VSR) ENDONUCLEASE FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 10360178

About this Structure

1VSR is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystallographic and functional studies of very short patch repair endonuclease., Tsutakawa SE, Muto T, Kawate T, Jingami H, Kunishima N, Ariyoshi M, Kohda D, Nakagawa M, Morikawa K, Mol Cell. 1999 May;3(5):621-8. PMID:10360178

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