2p3m

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[[Image:2p3m.jpg|left|200px]]
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{{STRUCTURE_2p3m| PDB=2p3m | SCENE= }}
{{STRUCTURE_2p3m| PDB=2p3m | SCENE= }}
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'''Solution structure of Mj0056'''
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===Solution structure of Mj0056===
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==Overview==
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Proteins of the cradle-loop barrel metafold are formed by duplication of a conserved betaalphabeta-element, suggesting a common evolutionary origin from an ancestral group of nucleic acid-binding proteins. The basal fold within this metafold, the RIFT barrel, is also found in a wide range of enzymes, whose homologous relationship with the nucleic acid-binding group is unclear. We have characterized a protein family that is intermediate in sequence and structure between the basal group of cradle-loop barrels and one family of RIFT-barrel enzymes, the riboflavin kinases. We report the structure, substrate-binding mode, and catalytic activity for one of these proteins, Methanocaldococcus jannaschii Mj0056, which is an archaeal riboflavin kinase. Mj0056 is unusual in utilizing CTP rather than ATP as the donor nucleotide, and sequence conservation in the relevant residues suggests that this is a general feature of archaeal riboflavin kinases.
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{{ABSTRACT_PUBMED_18073108}}
==About this Structure==
==About this Structure==
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2P3M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3M OCA].
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2P3M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3M OCA].
==Reference==
==Reference==
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[[Category: Riboflavin kinase]]
[[Category: Riboflavin kinase]]
[[Category: Rift barrel]]
[[Category: Rift barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:45:19 2008''

Revision as of 02:45, 29 July 2008

Image:2p3m.png

Template:STRUCTURE 2p3m

Solution structure of Mj0056

Template:ABSTRACT PUBMED 18073108

About this Structure

2P3M is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full experimental information is available from OCA.

Reference

A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels., Ammelburg M, Hartmann MD, Djuranovic S, Alva V, Koretke KK, Martin J, Sauer G, Truffault V, Zeth K, Lupas AN, Coles M, Structure. 2007 Dec;15(12):1577-90. PMID:18073108

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