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1xj7

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[[Image:1xj7.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1xj7| PDB=1xj7 | SCENE= }}
{{STRUCTURE_1xj7| PDB=1xj7 | SCENE= }}
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'''Complex Androgen Receptor LBD and RAC3 peptide'''
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===Complex Androgen Receptor LBD and RAC3 peptide===
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==Overview==
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Androgens drive sex differentiation, bone and muscle development, and promote growth of hormone-dependent cancers by binding the nuclear androgen receptor (AR), which recruits coactivators to responsive genes. Most nuclear receptors recruit steroid receptor coactivators (SRCs) to their ligand binding domain (LBD) using a leucine-rich motif (LXXLL). AR is believed to recruit unique coactivators to its LBD using an aromatic-rich motif (FXXLF) while recruiting SRCs to its N-terminal domain (NTD) through an alternate mechanism. Here, we report that the AR-LBD interacts with both FXXLF motifs and a subset of LXXLL motifs and that contacts with these LXXLL motifs are both necessary and sufficient for SRC-mediated AR regulation of transcription. Crystal structures of the activated AR in complex with both recruitment motifs reveal that side chains unique to the AR-LBD rearrange to bind either the bulky FXXLF motifs or the more compact LXXLL motifs and that AR utilizes subsidiary contacts with LXXLL flanking sequences to discriminate between LXXLL motifs.
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The line below this paragraph, {{ABSTRACT_PUBMED_15563469}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15563469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15563469}}
==About this Structure==
==About this Structure==
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[[Category: Webb, P.]]
[[Category: Webb, P.]]
[[Category: Androgen receptor coactivators lxxll motif]]
[[Category: Androgen receptor coactivators lxxll motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 15:06:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:47:40 2008''

Revision as of 02:47, 29 July 2008

Image:1xj7.png

Template:STRUCTURE 1xj7

Complex Androgen Receptor LBD and RAC3 peptide

Template:ABSTRACT PUBMED 15563469

About this Structure

1XJ7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor., Estebanez-Perpina E, Moore JM, Mar E, Delgado-Rodrigues E, Nguyen P, Baxter JD, Buehrer BM, Webb P, Fletterick RJ, Guy RK, J Biol Chem. 2005 Mar 4;280(9):8060-8. Epub 2004 Nov 24. PMID:15563469

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